2982945-41-3
2982945-41-3
Chemical Structure
PDE1-IN-9
- CAS No.: 2982945-41-3
- Formula:C28H31N3O2
- Molecular Weight:441.56
InChIKey: WNKZPQLJGGUBEG-UHFFFAOYSA-N
SMILES: N#CC1=C(C2CCCC2)C3=C(C=C(NCC4CCOCC4)C=C3)N(CC5=CC=CC=C5)C1=O
Biological Activity: PDE1-IN-9 (Compound 7a) is a selective inhibitor for phosphodiesterase 1 (PDE1), that inhibits PDE1C with an IC50 of 11 nM. PDE1-IN-9 reduces mRNA expression of IL-1β, IL-6, TNF-α and iNOS, inhibits the production of nitric oxide (NO) and reactive oxygen species (ROS). PDE1-IN-9 exhibits good metabolic stability in rat liver microsomes[1].
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PDE1-IN-9 | PDE1-IN-9 (Compound 7a) is a selective inhibitor for phosphodiesterase 1 (PDE1), that inhibits PDE1C with an IC50 of 11 nM. PDE1-IN-9 reduces mRNA expression of IL-1β, IL-6, TNF-α and iNOS, inhibits the production of nitric oxide (NO) and reactive oxygen species (ROS). PDE1-IN-9 exhibits good metabolic stability in rat liver microsomes. | |||||||||||||||||||||
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References
Keywords
