2998-57-4
Chemical Structure
Estramustine
- CAS No.: 2998-57-4
- Formula:C23H31Cl2NO3
- Molecular Weight:440.40
IUPAC Name: (8R,9S,13S,14S,17S)-17-hydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl bis(2-chloroethyl)carbamate
InChIKey: FRPJXPJMRWBBIH-RBRWEJTLSA-N
SMILES: C[C@@]12[C@](CC[C@@H]2O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(OC(N(CCCl)CCCl)=O)C=C4CC3
Biological Activity: Estramustine, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer[1][2][3].
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Estramustine | 99.15% | Estramustine, an estradiol analog, is an orally active antimicrotubule chemotherapy agent. Estramustine depolymerises microtubules by binding to microtubule associated proteins (MAPs) and/or to tubulin. Estramustine can interfere mitosis, trigger cell death and induce apoptosis, which can be used for the research of cancer like prostate cancer. | ||||||||||||||||||||
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Estramustine (Standard) | ≥98% | Estramustine (Standard) is the analytical standard of Estramustine. This product is intended for research and analytical applications. Estramustine is an antineoplastic agent. Estramustine depolymerizes microtnbules by binding to tubulin 1, exhibits antimitotic activity with an IC50 value of ~16 μM for mitosis of DU 145 cells. Estramustine blocks cells at mitosis in prostate tumor xenografts. | ||||||||||||||||||||
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Similarity Score 0.83
HY-13627AEstramustine phosphate -
Similarity Score 0.81
HY-126464Estromustine -
Similarity Score 0.81
HY-119587Alestramustine -
Similarity Score 0.78
HY-13627Estramustine phosphate sodium -
Similarity Score 0.75
HY-B0709Estradiol acetate -
Similarity Score 0.75
HY-Z2771Estradiol Valerate impurity 6 -
Similarity Score 0.72
HY-W008581Estradiol 3-methyl ether -
Similarity Score 0.69
HY-U00112Estradiol 3-sulfamate -
Similarity Score 0.67
HY-14167217β-Estradiol sulfate sodium -
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References
- [1]. C Wei, et al. Estramustine phosphate induces prostate cancer cell line PC3 apoptosis by down-regulating miR-31 levels. Eur Rev Med Pharmacol Sci. 2018 Jan;22(1):40-45. [Content Brief]
- [2]. Sonja S Mojsilovic, et al. Estramustine Phosphate Inhibits TGF- β-Induced Mouse Macrophage Migration and Urokinase-Type Plasminogen Activator Production. Anal Cell Pathol (Amst). 2018 Sep 2;2018:3134102. [Content Brief]
- [3]. Stephane Oudard, et al. Activity of docetaxel with or without estramustine phosphate versus mitoxantrone in androgen dependent and independent human prostate cancer xenografts. J Urol. 2003 May;169(5):1729-34. [Content Brief]
