3018909-73-1
3018909-73-1
Chemical Structure
IK-595
- CAS No.: 3018909-73-1
- Formula:C24H24ClFIN5O5S
- Molecular Weight:675.90
InChIKey: RDFUWPLPCIAPFU-UHFFFAOYSA-N
SMILES: CNS(=O)(NC1=C(C(OC2=C(C(N(C(NC3=C(C=C(I)C=C3)F)=C2C(NC4CC4)=O)C)=O)C)=CC=C1)Cl)=O
Biological Activity: IK-595 is a MEK1/MEK2 inhibitor with high affinity (7.39 nM).IK-595 blocks EGF-induced ERK1/2 phosphorylation in AsPC-1 cells with IC50 value of 0.1 nM. IK-595 has oral activity and blood-brain barrier penetration. IK-595 can be used for the research of Ras/MAPK pathway-altered cancers[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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IK-595 | 98.55% | IK-595 is a MEK1/MEK2 inhibitor with high affinity (7.39 nM).IK-595 blocks EGF-induced ERK1/2 phosphorylation in AsPC-1 cells with IC50 value of 0.1 nM. IK-595 has oral activity and blood-brain barrier penetration. IK-595 can be used for the research of Ras/MAPK pathway-altered cancers. | ||||||||||||||||||||
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References
Keywords
