3023854-95-4
Chemical Structure
TREK inhibitor-3
- CAS No.: 3023854-95-4
- Formula:C21H23NO2
- Molecular Weight:321.41
InChIKey: GRNPHPDIGUCBTP-UHFFFAOYSA-N
SMILES: O=C1C2=CC(C3CCNCC3)=CC=C2C(O1)CC4=CC=CC=C4C
Biological Activity: TREK inhibitor-3 (Cpd8l) is a selective and BBB-permeable TREK-1 inhibitor with an IC50 of 0.81 μM. TREK inhibitor-3 has neuroprotective effects, which can significantly reduce the death of cortical neurons induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and improve brain injury in mice models of middle cerebral artery occlusion/reperfusion (MCAO/R). TREK inhibitor-3 can be used in the research of ischemic stroke[1].
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TREK inhibitor-3 | TREK inhibitor-3 (Cpd8l) is a selective and BBB-permeable TREK-1 inhibitor with an IC50 of 0.81 μM. TREK inhibitor-3 has neuroprotective effects, which can significantly reduce the death of cortical neurons induced by oxygen-glucose deprivation/reoxygenation (OGD/R) and improve brain injury in mice models of middle cerebral artery occlusion/reperfusion (MCAO/R). TREK inhibitor-3 can be used in the research of ischemic stroke. | |||||||||||||||||||||
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Keywords
