3032113-20-2
3032113-20-2
Chemical Structure
EGFR-IN-91
- CAS No.: 3032113-20-2
- Formula:C22H25ClFN5O3
- Molecular Weight:461.92
InChIKey: OXIJKGCVPJOUEO-UHFFFAOYSA-N
SMILES: CN1CCN(OCCOC2=C(OC)C=C3N=CN=C(NC4=CC=CC(Cl)=C4F)C3=C2)CC1
Biological Activity: EGFR-IN-91 (compound 9) is an orally available EGFR inhibitor with blood-brain barrier penetrability. EGFR-IN-91 inhibits EGFRL858R/C797S and EGFRexon 19del/C797S, inducing tumor regression in xenograft (PDX) mouse models. EGFR-IN-91 has the potential to inhibit localized and metastatic non-small cell lung cancer (NSCLC) driven by EGFR mutants[1].
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EGFR-IN-91 | EGFR-IN-91 (compound 9) is an orally available EGFR inhibitor with blood-brain barrier penetrability. EGFR-IN-91 inhibits EGFRL858R/C797S and EGFRexon 19del/C797S, inducing tumor regression in xenograft (PDX) mouse models. EGFR-IN-91 has the potential to inhibit localized and metastatic non-small cell lung cancer (NSCLC) driven by EGFR mutants. | |||||||||||||||||||||
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References
Keywords
