3032401-50-3
3032401-50-3
Chemical Structure
Dyrk1A/B-IN-1
- CAS No.: 3032401-50-3
- Formula:C21H17N3O2S2
- Molecular Weight:407.51
IUPAC Name: 4-(5-((2-aminobenzyl)carbamoyl)thiophen-2-yl)benzo[b]thiophene-2-carboxamide
InChIKey: UQZFCZAYARDQIK-UHFFFAOYSA-N
SMILES: NC(C1=CC2=C(C=CC=C2S1)C3=CC=C(S3)C(NCC4=C(C=CC=C4)N)=O)=O
Biological Activity: Dyrk1A/B-IN-1 (compound 3n) is a potent, selective and cell-permeable DYRK1A and DYRK1B inhibitor with Kis of 67.8 nM and 237.9 nM, and IC50s of 1.1 μM and 0.8 μM, respectively. Dyrk1A/B-IN-1 is not toxic to human cells. Dyrk1A/B-IN-1 can be used for researching DYRK1A and DYRK1B cellular functions and their role in pathologies[1].
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Dyrk1A/B-IN-1 | Dyrk1A/B-IN-1 (compound 3n) is a potent, selective and cell-permeable DYRK1A and DYRK1B inhibitor with Kis of 67.8 nM and 237.9 nM, and IC50s of 1.1 μM and 0.8 μM, respectively. Dyrk1A/B-IN-1 is not toxic to human cells. Dyrk1A/B-IN-1 can be used for researching DYRK1A and DYRK1B cellular functions and their role in pathologies. | |||||||||||||||||||||
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