3033547-06-4
3033547-06-4
Chemical Structure
RET-IN-20
- CAS No.: 3033547-06-4
- Formula:C32H33FN6O4
- Molecular Weight:584.64
IUPAC Name: diethyl 3,3'-dihydroxy-[2,2'-bipyridine]-5,5'-dicarboxylate
InChIKey: VOBRHACDFXTQMQ-UHFFFAOYSA-N
SMILES: COC1=C(C=C2C(N=CC=C2OC3=CC=C(C=C3F)NC4=NN(C=C4C(NC56CC7CC(C6)CC(C5)C7)=O)C)=C1)C(N)=O
Biological Activity: RET-IN-20 is a potent RET inhibitor with an IC50 value of 13.7 nM. RET-IN-20 decreases the expression of p-Ret, p-Shc protein. RET-IN-20 induces apoptosis. RET-IN-20 shows antiproliferative and anti-tumor activity[1].
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RET-IN-20 | RET-IN-20 is a potent RET inhibitor with an IC50 value of 13.7 nM. RET-IN-20 decreases the expression of p-Ret, p-Shc protein. RET-IN-20 induces apoptosis. RET-IN-20 shows antiproliferative and anti-tumor activity. | |||||||||||||||||||||
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References
Keywords
