3033712-80-7
3033712-80-7
Chemical Structure
ATM Inhibitor-7
- CAS No.: 3033712-80-7
- Formula:C27H28N6O
- Molecular Weight:452.55
InChIKey: KAHMZYOZNYFPKN-LJQANCHMSA-N
SMILES: CN(C)CCCOC1=NC=C(C2=CC=C(N=CC3=C4N([C@H](C)C5=CC=CC=C5)N=N3)C4=C2)C=C1
Biological Activity: ATM Inhibitor-7 is a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor with an IC50 value of 1.0 nM. ATM Inhibitor-7 induces Apoptosis and cell cycle arrest at G2/M phase when combinanted with CPT-11 (HY-16562). ATM Inhibitor-7 combines with CPT-11 shows antitumor activity[1].
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ATM Inhibitor-7 | ATM Inhibitor-7 is a potent and selective ataxia-telangiectasia mutated (ATM) inhibitor with an IC50 value of 1.0 nM. ATM Inhibitor-7 induces Apoptosis and cell cycle arrest at G2/M phase when combinanted with CPT-11 (HY-16562). ATM Inhibitor-7 combines with CPT-11 shows antitumor activity. | |||||||||||||||||||||
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References
Keywords
