3033845-49-4
3033845-49-4
Chemical Structure
SIK-IN-3
- CAS No.: 3033845-49-4
- Formula:C24H25N5OS
- Molecular Weight:431.55
InChIKey: WMCHGBLGKMZDJD-XDHUDOTRSA-N
SMILES: N#CC1=CC=CC2=NC=C(C3=CC(OC[C@]4(N)[C@@H](CC)CCC4)=C(C#N)C(SC)=C3)N21
Biological Activity: SIK-IN-3 (Compound 6B) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.3 and 0.8 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.6 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 3 nM in human macrophages[1].
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SIK-IN-3 | SIK-IN-3 (Compound 6B) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.3 and 0.8 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC50 of 0.6 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 3 nM in human macrophages. | |||||||||||||||||||||
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References
Keywords
