3034676-53-1
Chemical Structure
JNK3 inhibitor-8
- CAS 番号: 3034676-53-1
- Formula:C32H30FN7O3
- Molecular Weight:579.62
IUPAC Name: (S)-1-(2-((1-(cyclopropanecarbonyl)piperidin-3-yl)amino)pyrimidin-4-yl)-4-fluoro-2-(naphthalen-2-yl)-1H-benzo[d]imidazol-6-yl methylcarbamate
InChIKey: CWLAIOPWFOOJHQ-QHCPKHFHSA-N
SMILES: O=C(N1C[C@@H](NC2=NC=CC(N3C4=C(N=C3C5=CC6=C(C=C5)C=CC=C6)C(F)=CC(OC(NC)=O)=C4)=N2)CCC1)C7CC7
Biological Activity: JNK3 inhibitor-8 is a potent, delective, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 21, 2203, >10000 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-8 shows significant neuroprotective effects. JNK3 inhibitor-8 has the potential for the research of Alzheimer’s disease (AD)[1].
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JNK3 inhibitor-8 | JNK3 inhibitor-8 is a potent, delective, orally active and cross the blood-brain barrier JNK3 inhibitor with IC50 values of 21, 2203, >10000 nM for JNK3, JNK2, JNK1, respectively. JNK3 inhibitor-8 shows significant neuroprotective effects. JNK3 inhibitor-8 has the potential for the research of Alzheimer’s disease (AD). | |||||||||||||||||||||
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Keywords
