3035072-99-9
3035072-99-9
Chemical Structure
RTx-303
- CAS No.: 3035072-99-9
- Formula:C24H22D3F7N4O4
- Molecular Weight:569.49
InChIKey: XOWJYFCVFGFEFB-LGKZJITBSA-N
SMILES: CN(C)C[C@@H](O)CN(C1=O)CCN1C2=C(OC(N(C([2H])([2H])[2H])C3=CC=C(F)C=C3)=O)C(C(F)(F)F)=CC(C(F)(F)F)=C2
Biological Activity: RTx-303 is an orally active, selective DNA polymerase θ (Polθ) inhibitor (IC50 = 5.1 nM). RTx-303 exhibits significantly high cellular potency and strongly potentiates PARPi in BRCA1/2 mutant cells and patient-derived xenograft models. RTx-303 can be used for the study of BRCA2-mutated breast cancer[1].
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RTx-303 | RTx-303 is an orally active, selective DNA polymerase θ (Polθ) inhibitor (IC50 = 5.1 nM). RTx-303 exhibits significantly high cellular potency and strongly potentiates PARPi in BRCA1/2 mutant cells and patient-derived xenograft models. RTx-303 can be used for the study of BRCA2-mutated breast cancer. | |||||||||||||||||||||
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References
Keywords
