3038183-53-5
3038183-53-5
Chemical Structure
JAK2/FLT3-IN-3
- CAS No.: 3038183-53-5
- Formula:C34H45N9O2
- Molecular Weight:611.78
InChIKey: SGEWLEOICXZSQI-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C(C)=O)C=C1)N(CC2)CCN2C3=NC(NC4=CC=C(N5CCC(N6CCN(C)CC6)CC5)C=C4)=NC=C3C
Biological Activity: JAK2/FLT3-IN-3 (11r) is a dual FLT3 and JAK2 inhibitor, with IC50 values of 2.01 nM, 0.51 nM and 104.40 nM for JAK2, FLT3 and JAK3, respectively. JAK2/FLT3-IN-3 (11r) induces apoptosis and possesses antitumor activity[1].
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JAK2/FLT3-IN-3 | JAK2/FLT3-IN-3 (11r) is a dual FLT3 and JAK2 inhibitor, with IC50 values of 2.01 nM, 0.51 nM and 104.40 nM for JAK2, FLT3 and JAK3, respectively. JAK2/FLT3-IN-3 (11r) induces apoptosis and possesses antitumor activity. | |||||||||||||||||||||
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References
Keywords
