JAK2/FLT3-IN-3
JAK2/FLT3-IN-3 (11r) is a dual FLT3 and JAK2 inhibitor, with IC50 values of 2.01 nM, 0.51 nM and 104.40 nM for JAK2, FLT3 and JAK3, respectively. JAK2/FLT3-IN-3 (11r) induces apoptosis and possesses antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 3038183-53-5
- Formula: C34H45N9O2
- Molecular Weight:611.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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JAK2 2.01 nM (IC50) |
FLT3 0.51 nM (IC50) |
JAK3 104.40 nM (IC50) |
JAK2/FLT3-IN-3 (11r) exerts potent antiproliferative activity against HEL (IC50 = 1.1 μM), MV4-11 (IC50 = 9.43 nM), RPMI-8226 (IC50 = 0.793 μM), NCI-H929 (IC50 = 0.743 μM), Ba/F3-FLT3-ITD-D835Y (IC50 = 0.099 μM), and Ba/F3-FLT3-ITD-F691L (IC50 = 0.042 μM) cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3038183-53-5
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Molecular Weight 611.78
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Formula C34H45N9O2
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SMILES
O=C(NC1=CC=C(C(C)=O)C=C1)N(CC2)CCN2C3=NC(NC4=CC=C(N5CCC(N6CCN(C)CC6)CC5)C=C4)=NC=C3C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK2/FLT3-IN-3 Related Classifications
HY-161967 Related Classifications
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