JAK2/FLT3-IN-3
JAK2/FLT3-IN-3 (11r) is a dual FLT3 and JAK2 inhibitor, with IC50 values of 2.01 nM, 0.51 nM and 104.40 nM for JAK2, FLT3 and JAK3, respectively. JAK2/FLT3-IN-3 (11r) induces apoptosis and possesses antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 3038183-53-5
- Formula: C34H45N9O2
- Molecular Weight:611.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
JAK2 2.01 nM (IC50) |
FLT3 0.51 nM (IC50) |
JAK3 104.40 nM (IC50) |
In Vitro
JAK2/FLT3-IN-3 (11r) exerts potent antiproliferative activity against HEL (IC50 = 1.1 μM), MV4-11 (IC50 = 9.43 nM), RPMI-8226 (IC50 = 0.793 μM), NCI-H929 (IC50 = 0.743 μM), Ba/F3-FLT3-ITD-D835Y (IC50 = 0.099 μM), and Ba/F3-FLT3-ITD-F691L (IC50 = 0.042 μM) cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Chemical Information
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CAS No. 3038183-53-5
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Molecular Weight 611.78
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Formula C34H45N9O2
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SMILES
O=C(NC1=CC=C(C(C)=O)C=C1)N(CC2)CCN2C3=NC(NC4=CC=C(N5CCC(N6CCN(C)CC6)CC5)C=C4)=NC=C3C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JAK2/FLT3-IN-3 Related Classifications
HY-161967 Related Classifications
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