3038340-43-8
3038340-43-8
Chemical Structure
JAK2-IN-21
- CAS No.: 3038340-43-8
- Formula:C25H19NO4
- Molecular Weight:397.42
InChIKey: SJHFHTVXXUAYFK-UHFFFAOYSA-N
SMILES: O=C(C1=CC=CC=C1)C2=C(O)C(NC(C3=CC=CC=C3)=O)=CC4=CC=C(OC)C=C42
Biological Activity: JAK2-IN-21 is a Janus kinase 2 (JAK2) inhibitor with an IC50 of 12.25 nM. JAK2-IN-21 inhibits the JAK2/STAT3/STAT5 tumor-promoting signaling pathway and reduces JAK2 protein expression. JAK2-IN-21 exhibits selective cytotoxicity against HPV-positive cancer cells and induces cancer cell apoptosis. JAK2-IN-21 can be used in the research of HPV-positive cervical cancer[1].
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JAK2-IN-21 | JAK2-IN-21 is a Janus kinase 2 (JAK2) inhibitor with an IC50 of 12.25 nM. JAK2-IN-21 inhibits the JAK2/STAT3/STAT5 tumor-promoting signaling pathway and reduces JAK2 protein expression. JAK2-IN-21 exhibits selective cytotoxicity against HPV-positive cancer cells and induces cancer cell apoptosis. JAK2-IN-21 can be used in the research of HPV-positive cervical cancer. | |||||||||||||||||||||
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