3038691-85-6
Chemical Structure
HDAC1/6-IN-3
- CAS No.: 3038691-85-6
- Formula:C24H27N3O4S
- Molecular Weight:453.55
IUPAC Name: N1-hydroxy-N7-(4-methoxyphenyl)-N7-((2-phenylthiazol-4-yl)methyl)heptanediamide
InChIKey: AJUUKIZUUCXJFE-UHFFFAOYSA-N
SMILES: O=C(NO)CCCCCC(N(C1=CC=C(OC)C=C1)CC2=CSC(C3=CC=CC=C3)=N2)=O
Biological Activity: HDAC1/6-IN-3 is a potent HDAC inhibitor. HDAC1/6-IN-3 shows excellent inhibitory activities against HDAC1 (IC50 = 1.1 nM) and HDAC6 (IC50 = 2.7 nM). HDAC1/6-IN-3 significantly arrests HepG2 cells at the G0/G1 phase and induces apoptosis and pyroptosis. HDAC1/6-IN-3 exhibits significant antitumor activity in the HepG2 xenograft mode. HDAC1/6-IN-3 can be used for the study of cancers such as liver cancer, lung cancer, colon cancer and breast cancer[1].
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HDAC1/6-IN-3 | HDAC1/6-IN-3 is a potent HDAC inhibitor. HDAC1/6-IN-3 shows excellent inhibitory activities against HDAC1 (IC50 = 1.1 nM) and HDAC6 (IC50 = 2.7 nM). HDAC1/6-IN-3 significantly arrests HepG2 cells at the G0/G1 phase and induces apoptosis and pyroptosis. HDAC1/6-IN-3 exhibits significant antitumor activity in the HepG2 xenograft mode. HDAC1/6-IN-3 can be used for the study of cancers such as liver cancer, lung cancer, colon cancer and breast cancer. | |||||||||||||||||||||
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