30414-15-4
30414-15-4
Chemical Structure
N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine
- CAS No.: 30414-15-4
- Formula:C20H20N2O11
- Molecular Weight:464.38
InChIKey: KLXJDVFEFZPIMN-RYUDHWBXSA-N
SMILES: O=C(C1=C(C(O)=CC=C1)O)N[C@H](C(O)=O)COC([C@H](CO)NC(C2=C(C(O)=CC=C2)O)=O)=O
Biological Activity: N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine is a enterochelin hydrolyzed product. N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine can inhibit the invasion of murine colon cancer cells 26-L5 with an IC50 of 2.7 μM, and has anti-tumor effect. In addition, N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine has no appreciable antimicrobial activities against Micrococcus luteus, Escherichia coli and Candida albicans[1][2].
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N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine | N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine is a enterochelin hydrolyzed product. N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine can inhibit the invasion of murine colon cancer cells 26-L5 with an IC50 of 2.7 μM, and has anti-tumor effect. In addition, N,N'-Bis(2,3-Dihydroxybenzoyl)-O-L-seryl-L-serine has no appreciable antimicrobial activities against Micrococcus luteus, Escherichia coli and Candida albicans. | |||||||||||||||||||||
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References
- [1]. Igarashi Y, et al. Catechoserine, a new catecholate-type inhibitor of tumor cell invasion from Streptomyces sp. J Antibiot (Tokyo). 2012 Apr;65(4):207-9. [Content Brief]
- [2]. O'Brien IG, et al. Enterochelin hydrolysis and iron metabolism in Escherichia coli. Biochim Biophys Acta. 1971 Jun 22;237(3):537-49. [Content Brief]
