3046153-44-7
3046153-44-7
Chemical Structure
MCR-1-IN-1
- CAS No.: 3046153-44-7
- Formula:C27H33BrClN3O3
- Molecular Weight:562.93
InChIKey: PLEXJAHBTOTNNR-UHFFFAOYSA-N
SMILES: N#CC1=C(N)OC2=C(C=CC(OCC(O)CNCCCCCCCC)=C2)C1C3=CC=C(Cl)C(Br)=C3
Biological Activity: MCR-1-IN-1 is an MCR-1 inhibitor with a Kd of 54 μM for E. coli MCR-1. MCR-1-IN-1 alone shows no significant growth inhibition against Mcr-1-positive E. coli. MCR-1-IN-1 produces a synergistic effect with Colistin in Mcr-1-positive E. coli, restoring Colistin sensitivity. MCR-1-IN-1 combined with Colistin improves survival and reduces bacterial burden in a mouse peritonitis infection model[1].
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MCR-1-IN-1 | MCR-1-IN-1 is an MCR-1 inhibitor with a Kd of 54 μM for E. coli MCR-1. MCR-1-IN-1 alone shows no significant growth inhibition against Mcr-1-positive E. coli. MCR-1-IN-1 produces a synergistic effect with Colistin in Mcr-1-positive E. coli, restoring Colistin sensitivity. MCR-1-IN-1 combined with Colistin improves survival and reduces bacterial burden in a mouse peritonitis infection model. | |||||||||||||||||||||
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