3047557-92-3
Chemical Structure
ADP-ribose/PARP-IN-1
- CAS No.: 3047557-92-3
- Formula:C92H125FN16O26
- Molecular Weight:1890.07
InChIKey: WMUVSCHVKPFEDP-NZLJJWAISA-N
SMILES: O=C1C2=C3C(CCN1)=C(C4=CC=C(C=C4)CN(C)C(CCCCCCC(NCCCC[C@@H](NC(CCC(N5CCN(CCN(CCN(CC5)CC(O)=O)CC(O)=O)CC(O)=O)C(O)=O)=O)C(N[C@H](CC(O)=O)C(NCCC(NC[C@@H]6CC[C@H](CC6)C(N[C@H](C(NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)CC7=CC8=C(C=CC=C8)C=C7)=O)=O)=O)=O)=O)=O)NC3=CC(F)=C2
Biological Activity: ADP-ribose/PARP-IN-1 (Compound Ex.16) is a conjugated compound. ADP-ribose/PARP-IN-1 contains disease targeting moieties, PARP inhibitor moieties, cleavable linkers, chelators. ADP-ribose/PARP-IN-1 targets specific targets through the disease targeting moiety and selectively delivers PARP inhibitors to tumor cells. The cleavable linker of ADP-ribose/PARP-IN-1 releases the PARP inhibitor under appropriate conditions, inhibiting PARP to prevent DNA damage repair, while the radionuclide carried by the chelator exerts a killing effect. ADP-ribose/PARP-IN-1 can be used in the research of prostate cancer[1].
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ADP-ribose/PARP-IN-1 | ADP-ribose/PARP-IN-1 (Compound Ex.16) is a conjugated compound. ADP-ribose/PARP-IN-1 contains disease targeting moieties, PARP inhibitor moieties, cleavable linkers, chelators. ADP-ribose/PARP-IN-1 targets specific targets through the disease targeting moiety and selectively delivers PARP inhibitors to tumor cells. The cleavable linker of ADP-ribose/PARP-IN-1 releases the PARP inhibitor under appropriate conditions, inhibiting PARP to prevent DNA damage repair, while the radionuclide carried by the chelator exerts a killing effect. ADP-ribose/PARP-IN-1 can be used in the research of prostate cancer. | |||||||||||||||||||||
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Keywords
