3047875-57-7
Chemical Structure
GLP-1R agonist 32
- CAS No.: 3047875-57-7
- Formula:C32H31ClFN3O5
- Molecular Weight:592.06
InChIKey: JBTKOFBLOBCVLQ-FIPFOOKPSA-N
SMILES: ClC(C=C1)=CC=C1[C@H]2OC3=CC=CC(C(CC4)CCN4CC(N(C5=CC(C(O)=O)=C6)C[C@@H]7CCO7)=NC5=C6F)=C3OC2
Biological Activity: GLP-1R agonist 32 (Compound 111) is an orally active and highly potent GLP-1R agonist with an EC50 value of 0.017 nM. GLP-1R agonist 32 exerts glucose-regulating activity by activating GLP-1R to stimulate cAMP production, promoting insulin secretion, inhibiting glucagon release, and delaying gastric emptying. GLP-1R agonist 32 is promising for research of type 2 diabetes, obesity, and related metabolic disorders[1].
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GLP-1R agonist 32 | GLP-1R agonist 32 (Compound 111) is an orally active and highly potent GLP-1R agonist with an EC50 value of 0.017 nM. GLP-1R agonist 32 exerts glucose-regulating activity by activating GLP-1R to stimulate cAMP production, promoting insulin secretion, inhibiting glucagon release, and delaying gastric emptying. GLP-1R agonist 32 is promising for research of type 2 diabetes, obesity, and related metabolic disorders. | |||||||||||||||||||||
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