3049092-06-7
3049092-06-7
Chemical Structure
WRN inhibitor 10
- CAS No.: 3049092-06-7
- Formula:C31H29BrClN9O5S
- Molecular Weight:755.04
InChIKey: CKTUPPMFQCRWSG-UHFFFAOYSA-N
SMILES: O=C(N1CCN(CC1)C2=C(N(C3=NC(C4=CC5=C(S4)COC5)=NN3C2=O)CC(NC6=CC=C(C=C6Cl)Br)=O)CC)C7=NC=NC(C)=C7O
Biological Activity: WRN inhibitor 10 (Compound P24) is an inhibitor for the Werner helicase WRN with an IC50 of 1.1 nM. WRN inhibitor 10 inhibits the proliferation of cancer cell SW48 with IC50 of 39 nM. WRN inhibitor 10 exhibits good liver microsomal stability and film permeability. WRN inhibitor 10 exhibits good pharmacokinetic characteristics in CD-1 mice[1].
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WRN inhibitor 10 | WRN inhibitor 10 (Compound P24) is an inhibitor for the Werner helicase WRN with an IC50 of 1.1 nM. WRN inhibitor 10 inhibits the proliferation of cancer cell SW48 with IC50 of 39 nM. WRN inhibitor 10 exhibits good liver microsomal stability and film permeability. WRN inhibitor 10 exhibits good pharmacokinetic characteristics in CD-1 mice. | |||||||||||||||||||||
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References
Keywords
