3052084-77-9
3052084-77-9
Chemical Structure
CDD-2789
- CAS No.: 3052084-77-9
- Formula:C26H34N4O4
- Molecular Weight:466.57
InChIKey: QSAGTNCQQMIGRY-UHFFFAOYSA-N
SMILES: COC1=C(OC)C=C(C2=NC(C=CC(C(NCCCN(C)C)=O)=C3)=C3N2C4CCC4)C=C1OC
Biological Activity: CDD-2789 is a potent and selective ALK2 inhibitor with an IC50 0.54 μM and a Kd of 2.1 nM, respectively. CDD-2789 exhibits >120-fold selectivity over ALK3/5/6. CDD-2789 reduces activin A- and BMP2-induced SMAD1/5 phosphorylation in fibroblasts. CDD-2789 can be used for ALK2-related cancer research[1].
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CDD-2789 | CDD-2789 is a potent and selective ALK2 inhibitor with an IC50 0.54 μM and a Kd of 2.1 nM, respectively. CDD-2789 exhibits >120-fold selectivity over ALK3/5/6. CDD-2789 reduces activin A- and BMP2-induced SMAD1/5 phosphorylation in fibroblasts. CDD-2789 can be used for ALK2-related cancer research. | |||||||||||||||||||||
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References
Keywords
