305333-99-7
305333-99-7
Chemical Structure
SE486-11
- CAS No.: 305333-99-7
- Formula:C26H20N4O
- Molecular Weight:404.46
InChIKey: IFZMQAGUUHLQQG-UHFFFAOYSA-N
SMILES: CC1=C(C#N)C2=NC3=C(C=CC=C3)N2C(NC4=CC=C(O)C=C4)=C1CC5=CC=CC=C5
Biological Activity: SE486-11 is an orally active USP5 inhibitor. SE486-11 increases free polyubiquitin chains and promotes the ubiquitination and degradation of MYCN. The combination of SE486-11 with SAHA (HY-10221) synergistically induces Apoptosis. SE486-11 can be used in research related to MYCN-driven neuroblastoma[1][2].
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SE486-11 | SE486-11 is an orally active USP5 inhibitor. SE486-11 increases free polyubiquitin chains and promotes the ubiquitination and degradation of MYCN. The combination of SE486-11 with SAHA (HY-10221) synergistically induces Apoptosis. SE486-11 can be used in research related to MYCN-driven neuroblastoma. | |||||||||||||||||||||
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References
- [1]. Cheung BB, et al. A novel combination therapy targeting ubiquitin-specific protease 5 in MYCN-driven neuroblastoma. Oncogene. 2021 Apr;40(13):2367-2381.
- [2]. Gadde S, et al. Pyrimido[1,2-a]benzimidazoles as inhibitors of oncoproteins ubiquitin specific protease 5 and MYCN in the childhood cancer neuroblastoma. Bioorg Chem. 2023 Jul;136:106462.
Keywords
