3055321-14-4
Chemical Structure
VVD-849
- CAS No.: 3055321-14-4
- Formula:C29H31ClFN3O6S2
- Molecular Weight:636.15
IUPAC Name: (S,Z)-1-((5-chloro-3'-(pyridin-2-ylmethoxy)-[1,1'-biphenyl]-2-yl)sulfonyl)-4-fluoro-N-(4-(methylsulfonyl)but-3-en-2-yl)piperidine-4-carboxamide
InChIKey: FZLIJGIXJASMPK-LRJKXPEMSA-N
SMILES: ClC1=CC(C2=CC(OCC3=NC=CC=C3)=CC=C2)=C(S(N4CCC(C(N[C@@H](C)/C=C\S(C)(=O)=O)=O)(F)CC4)(=O)=O)C=C1
Biological Activity: VVD-849 is a RAS ligand. VVD-849 covalently binds to Cys242 in the RAS-binding domain of PI3K p110α and promotes RAS/PI3K interaction. VVD-849 partially inhibits pAKT (S473) in HER2-overexpressing tumors. VVD-849 can be used for the research of cancers such as breast cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
VVD-849 | 99.76% | VVD-849 is a RAS ligand. VVD-849 covalently binds to Cys242 in the RAS-binding domain of PI3K p110α and promotes RAS/PI3K interaction. VVD-849 partially inhibits pAKT (S473) in HER2-overexpressing tumors. VVD-849 can be used for the research of cancers such as breast cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Klebba JE, et al. Covalent inhibitors of the RAS binding domain of PI3Kα impair tumor growth driven by RAS and HER2. bioRxiv [Preprint]. 2024 Dec 20:2024.12.17.629001. [Content Brief]
- [2]. Klebba JE, et al. Covalent inhibitors of the PI3Kα RAS binding domain impair tumor growth driven by RAS and HER2. Science. 2025 Nov 13;390(6774):702-709. [Content Brief]
Keywords
