3055537-47-5
Chemical Structure
VU6066098
- CAS No.: 3055537-47-5
- Formula:C19H17N3O
- Molecular Weight:303.36
InChIKey: RDXHRXNWTCRFGA-UHFFFAOYSA-N
SMILES: CC1=NN(C)C(C2=CC(C3=CC=CC=C3)=CC4=C2CNC4=O)=C1
Biological Activity: VU6066098 is a blood-brain barrier penetrant, orally active inhibitor of metabotropic glutamate receptor subtype 2 (mGlu2), with IC50 values of 77 nM and 111 nM against human and rat targets, respectively. VU6066098 induces antidepressant-like activity, inhibits psychosis-like hyperlocomotion, enhances recognition memory and associative learning, and reverses cognitive deficits caused by blast-related traumatic brain injury. VU6066098 can be used in research on major depressive disorder, schizophrenia, Alzheimer's disease, and traumatic brain injury[1].
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VU6066098 | VU6066098 is a blood-brain barrier penetrant, orally active inhibitor of metabotropic glutamate receptor subtype 2 (mGlu2), with IC50 values of 77 nM and 111 nM against human and rat targets, respectively. VU6066098 induces antidepressant-like activity, inhibits psychosis-like hyperlocomotion, enhances recognition memory and associative learning, and reverses cognitive deficits caused by blast-related traumatic brain injury. VU6066098 can be used in research on major depressive disorder, schizophrenia, Alzheimer's disease, and traumatic brain injury. | |||||||||||||||||||||
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Keywords
