3056226-40-2
3056226-40-2
Chemical Structure
(R)-LS01-64
- CAS No.: 3056226-40-2
- Formula:C25H31ClN2O
- Molecular Weight:410.98
InChIKey: PXLZPYQDTASRQC-WMTXJRDZSA-N
SMILES: ClC(C=C1)=CC=C1[C@H](C2)[C@@H]2NCC[C@]3(CCOC4(CCCC4)C3)C5=CC=CC=N5
Biological Activity: (R)-LS01-64 is a blood-brain barrier-penetrant μ opioid receptor (MOR) partial agonist and dopamine D3 receptor (D3R) inhibitor. (R)-LS01-64 binds to human MOR and D3R with Ki values of 22.3 nM and 138 nM, respectively, activates MOR signaling, and inhibits D3R-mediated G protein activation. (R)-LS01-64 can be used for pain research[1].
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(R)-LS01-64 | (R)-LS01-64 is a blood-brain barrier-penetrant μ opioid receptor (MOR) partial agonist and dopamine D3 receptor (D3R) inhibitor. (R)-LS01-64 binds to human MOR and D3R with Ki values of 22.3 nM and 138 nM, respectively, activates MOR signaling, and inhibits D3R-mediated G protein activation. (R)-LS01-64 can be used for pain research. | |||||||||||||||||||||
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