3062175-62-3
3062175-62-3
Chemical Structure
FAK-IN-24
- CAS No.: 3062175-62-3
- Formula:C39H45Cl2F3N8O3
- Molecular Weight:801.73
SMILES: O=C(CCCC1=CC=C(N(CCCl)CCCl)C=C1)OCCN2CCN(CC2)C3=CC=C(NC4=NC=C(C(F)(F)F)C(NC5=C(C(NC)=O)C=CC=C5)=N4)C=C3
Biological Activity: FAK-IN-24 (Compound 9f) is a FAK inhibitor (IC50: 0.815 nM). FAK-IN-24 induces DNA damage and apoptosis. FAK-IN-24 has anti-glioblastoma activity. FAK-IN-24 inhibits proliferation of glioblastoma cell lines U87-MG (IC50 = 15 nM) and U251 (IC50 = 20 nM). FAK-IN-24 inhibits tumor growth in U87-MG xenograft model[1].
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FAK-IN-24 | FAK-IN-24 (Compound 9f) is a FAK inhibitor (IC50: 0.815 nM). FAK-IN-24 induces DNA damage and apoptosis. FAK-IN-24 has anti-glioblastoma activity. FAK-IN-24 inhibits proliferation of glioblastoma cell lines U87-MG (IC50 = 15 nM) and U251 (IC50 = 20 nM). FAK-IN-24 inhibits tumor growth in U87-MG xenograft model. | |||||||||||||||||||||
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References
Keywords
