3063893-60-4
3063893-60-4
Chemical Structure
PLK1/BRD4-IN-5
- CAS No.: 3063893-60-4
- Formula:C31H44N8O3
- Molecular Weight:576.73
InChIKey: LBAXGISUFHVKPW-JXALWOEJSA-N
SMILES: CC[C@@H]1C(N(C2=CN=C(N=C2N1C3CCCC3)NC4=C(C=C5C(CCN5C(CN6C[C@@H](N[C@@H](C6)C)C)=O)=C4)OC)C)=O
Biological Activity: PLK1/BRD4-IN-5 (Compound SC10) is an orally active PLK1 and BRD4 inhibitor with IC50 values of 0.3 nM and 60.8 nM, respectively. PLK1/BRD4-IN-5 can induce MV4-11 cell block in S phase and apoptosis) in a dose-dependent manner. PLK1/BRD4-IN-5 can be used in cancer research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PLK1/BRD4-IN-5 | 98.80% | PLK1/BRD4-IN-5 (Compound SC10) is an orally active PLK1 and BRD4 inhibitor with IC50 values of 0.3 nM and 60.8 nM, respectively. PLK1/BRD4-IN-5 can induce MV4-11 cell block in S phase and apoptosis) in a dose-dependent manner. PLK1/BRD4-IN-5 can be used in cancer research. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.73
HY-181051PLK1-IN-16 -
Similarity Score 0.65
HY-50698A(S)-BI 2536 -
Similarity Score 0.65
HY-50698GBI 2536 (GMP) -
Similarity Score 0.64
HY-75578dTAG Targeting Ligand 1 -
Similarity Score 0.63
HY-173212PLK1-IN-13 -
Similarity Score 0.62
HY-149100PLK1-IN-6 -
Similarity Score 0.60
HY-160557PLK1/BRD4-IN-2 -
Similarity Score 0.59
HY-12137Volasertib -
Similarity Score 0.59
HY-160558PLK1/BRD4-IN-3 -
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