3064280-41-4
Chemical Structure
PRMT5-IN-57
- CAS No.: 3064280-41-4
- Formula:C27H23FN8O
- Molecular Weight:494.52
InChIKey: FTFFGRIARYPFLM-UHFFFAOYSA-N
SMILES: CN1C=C(C=N1)C#CC2=CC=C(N=C2)CN(C3CC3)C(C4=C(C=C5N=C(C6=C(N(N=C6)C)C5=C4)N)F)=O
Biological Activity: PRMT5-IN-57 is an orally active andselective MTA-cooperative PRMT5 inhibitor, with an IC50 of 8.39 nM against PRMT5/MTA complex. PRMT5-IN-57 exhibits potent and selective antiproliferative activity against MTAP-null cancer cells. PRMT5-IN-57 demonstrates significant in vivo antitumor efficacy in an HCT116 MTAP-/- CDX model. PRMT5-IN-57 can be used for the research of MTAP-deleted cancers[1].
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PRMT5-IN-57 | PRMT5-IN-57 is an orally active andselective MTA-cooperative PRMT5 inhibitor, with an IC50 of 8.39 nM against PRMT5/MTA complex. PRMT5-IN-57 exhibits potent and selective antiproliferative activity against MTAP-null cancer cells. PRMT5-IN-57 demonstrates significant in vivo antitumor efficacy in an HCT116 MTAP-/- CDX model. PRMT5-IN-57 can be used for the research of MTAP-deleted cancers. | |||||||||||||||||||||
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Keywords
