3067565-40-3
Chemical Structure
iNOs-IN-5
- CAS No.: 3067565-40-3
- Formula:C22H27N3O2
- Molecular Weight:365.47
InChIKey: APGDMVQLMOYVGT-UHFFFAOYSA-N
SMILES: O=C(OC1CCCC)C2=C1C=CC(NCC3=CC(CNC(C)=N)=CC=C3)=C2
Biological Activity: iNOs-IN-5 (Compound BN-4) is an inhibitor for iNOS with an IC50 of 0.1707 μM, and reduces NO levels in LPS (HT-D1056)-induced RAW264.7 cells. iNOs-IN-5 reduces the hypoxic injury stimulated ROS and lactate dehydrogenase expression, and exhibits anti-necrosis and anti-apoptosis efficacy. iNOs-IN-5 exhibits anti-cerebral ischemia and neuroprotective activities in SD rat models. iNOs-IN-5 is blood-brain barrier penetrable[1].
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iNOs-IN-5 | iNOs-IN-5 (Compound BN-4) is an inhibitor for iNOS with an IC50 of 0.1707 μM, and reduces NO levels in LPS (HT-D1056)-induced RAW264.7 cells. iNOs-IN-5 reduces the hypoxic injury stimulated ROS and lactate dehydrogenase expression, and exhibits anti-necrosis and anti-apoptosis efficacy. iNOs-IN-5 exhibits anti-cerebral ischemia and neuroprotective activities in SD rat models. iNOs-IN-5 is blood-brain barrier penetrable. | |||||||||||||||||||||
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Keywords
