3067908-20-4
Chemical Structure
Enpp-1-IN-25
- CAS No.: 3067908-20-4
- Formula:C15H21N5O4S
- Molecular Weight:367.42
SMILES: COC1=C(C2=CC=C1)N=CN=C2N3CCC(CNS(=O)(N)=O)(CC3)O
Biological Activity: Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and low oral bioavailability. Enpp-1-IN-25 can effectively activate the intracellular STING pathway by inhibiting cGAMP degradation. Enpp-1-IN-25 can enhance immune cell infiltration in the tumor microenvironment and type I interferon responses, and potentiate the antitumor efficacy of the anti-PD-L1 antibody. Enpp-1-IN-25 can be used in the research of cancer immunotherapy[1].
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Enpp-1-IN-25 | Enpp-1-IN-25 (Compound 30) is an ENPP1 inhibitor with an IC50 of 8.05 nM and low oral bioavailability. Enpp-1-IN-25 can effectively activate the intracellular STING pathway by inhibiting cGAMP degradation. Enpp-1-IN-25 can enhance immune cell infiltration in the tumor microenvironment and type I interferon responses, and potentiate the antitumor efficacy of the anti-PD-L1 antibody. Enpp-1-IN-25 can be used in the research of cancer immunotherapy. | |||||||||||||||||||||
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Keywords
