3068255-86-4
3068255-86-4
Chemical Structure
EP4 receptor antagonist 8
- CAS No.: 3068255-86-4
- Formula:C26H21ClN6O4
- Molecular Weight:516.94
InChIKey: HETPOMLFMVUOQF-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(CNC(C2=C3C=CC=CC3=NN2CCNC(NC4=CC=C(C#N)C=C4Cl)=O)=O)C=C1
Biological Activity: EP4 receptor antagonist 8 is an orally active EP4 antagonist (human EP4 IC50 = 6.40 nM). EP4 receptor antagonist 8 significantly reduced paw and joint swelling, inflammatory cell infiltration, cartilage damage, pannus formation, and joint bone erosion in arthritis (AIA) mice in a dose-dependent manner. EP4 receptor antagonist 8 can be used for the study of inflammatory pain[1].
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EP4 receptor antagonist 8 | EP4 receptor antagonist 8 is an orally active EP4 antagonist (human EP4 IC50 = 6.40 nM). EP4 receptor antagonist 8 significantly reduced paw and joint swelling, inflammatory cell infiltration, cartilage damage, pannus formation, and joint bone erosion in arthritis (AIA) mice in a dose-dependent manner. EP4 receptor antagonist 8 can be used for the study of inflammatory pain. | |||||||||||||||||||||
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