3068547-01-0
3068547-01-0
Chemical Structure
DS22
- CAS No.: 3068547-01-0
- Formula:C21H22Cl2N10O
- Molecular Weight:501.37
InChIKey: QUGBKWYKYATQSZ-LLVKDONJSA-N
SMILES: CC[C@@H](NC1=NC(NCC2=NC3=CC(Cl)=C(Cl)C=C3N2)=C4C(N(C5=CN(C)N=C5)C=N4)=N1)CO
Biological Activity: DS22 is a CDK12-cyclin K molecular glue degrader. DS22 promotes the formation of the DDB1-CDK12-cyclin K ternary complex, with an EC50 of 19 nM. DS22 can be used in research related to CDK12-mediated diseases, such as cancer[1].
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DS22 | DS22 is a CDK12-cyclin K molecular glue degrader. DS22 promotes the formation of the DDB1-CDK12-cyclin K ternary complex, with an EC50 of 19 nM. DS22 can be used in research related to CDK12-mediated diseases, such as cancer. | |||||||||||||||||||||
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