3068938-30-4
Chemical Structure
NEURL1B-IN-1
- CAS No.: 3068938-30-4
- Formula:C30H38O5
- Molecular Weight:478.62
InChIKey: PUYBSDITWAGSJI-JZLIFRCSSA-N
SMILES: [H][C@@]12C[C@H]3[C@H](OC([C@@]34C[C@@H]5C[C@]4(C6=C5[C@@](O)(CC[C@H]7C(C(O[C@H]67)=O)=C)C)C)=O)C[C@]1(CCCC2=C)C
Biological Activity: NEURL1B-IN-1 is a molecular glue-like NEURL1B degrader with a Kd value of 46.2 nM. NEURL1B-IN-1 binds to Arg422 within the NHR2 domain of NEURL1B, triggers its autoubiquitination and proteasomal degradation, disrupts its interaction with DLL1, and attenuates the Notch signaling pathway. NEURL1B-IN-1 induces cell cycle arrest and apoptosis, and inhibits migration of hepatocellular carcinoma cells. NEURL1B-IN-1 is applicable to research related to hepatocellular carcinoma[1].
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NEURL1B-IN-1 | NEURL1B-IN-1 is a molecular glue-like NEURL1B degrader with a Kd value of 46.2 nM. NEURL1B-IN-1 binds to Arg422 within the NHR2 domain of NEURL1B, triggers its autoubiquitination and proteasomal degradation, disrupts its interaction with DLL1, and attenuates the Notch signaling pathway. NEURL1B-IN-1 induces cell cycle arrest and apoptosis, and inhibits migration of hepatocellular carcinoma cells. NEURL1B-IN-1 is applicable to research related to hepatocellular carcinoma. | |||||||||||||||||||||
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Keywords
