307002-73-9
307002-73-9
Chemical Structure
WAY-170523
- CAS. Nr.: 307002-73-9
- Formula:C33H31N3O7S
- Molecular Weight:613.68
IUPAC Name: N-(2-(4-(N-benzyl-N-(2-(hydroxycarbamoyl)-4,6-dimethylphenyl)sulfamoyl)phenoxy)ethyl)benzofuran-2-carboxamide
InChIKey: FARMEEAGJWMFSZ-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(C=CC=C2)O1)NCCOC3=CC=C(S(=O)(N(CC4=CC=CC=C4)C5=C(C)C=C(C)C=C5C(NO)=O)=O)C=C3
Biological Activity: WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC50 of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research[1][2].
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WAY-170523 | WAY-170523 is a potent and selective MMP-13 (matrix metalloproteinase-13) inhibitor, with an IC50 of 17 nM. WAY-170523 can directly attenuate ERK1/2 phosphorylation. WAY-170523 inhibits the invasion of PC-3 cells, can be used for prostate cancer research. | |||||||||||||||||||||
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References
- [1]. James M. Chen, et al. Structure-Based Design of a Novel, Potent, and Selective Inhibitor for MMP-13 Utilizing NMR Spectroscopy and Computer-Aided Molecular Design. J. Am. Chem. Soc. 2000, 122, 40, 9648-9654.
- [2]. Mervi Toriseva, et al. Phenotypic screening using AMIDA identifies different drug responses in breast and prostate cancer cell lines in an organotypic cell culture model. Cancer Res (2018) 78 (13_Supplement): 1158.
