3075750-60-3
Chemical Structure
SG16
Synonym(s): Keap1-Nrf2-IN-28
- CAS No.: 3075750-60-3
- Formula:C22H16FNO5S
- Molecular Weight:425.43
InChIKey: KWCUNVGUQPKBAS-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(F)C=C1)(NC2=CC3=C(C=C2)C(C=C(C4=CC=C(OC)C=C4)O3)=O)=O
Biological Activity: SG16 (Keap1-Nrf2-IN-28) is an orally active Keap1-Nrf2 inhibitor. SG16 disrupts the binding of Keap1 to Nrf2, promotes the nuclear translocation of Nrf2, upregulates the downstream antioxidant proteins HO-1 and GCLM, and simultaneously inhibits microglial overactivation and proinflammatory cytokine secretion. By activating the Nrf2 pathway, SG16 can be used in studies on oxidative stress, ischemic stroke and acute liver injury[1][2].
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SG16 | SG16 (Keap1-Nrf2-IN-28) is an orally active Keap1-Nrf2 inhibitor. SG16 disrupts the binding of Keap1 to Nrf2, promotes the nuclear translocation of Nrf2, upregulates the downstream antioxidant proteins HO-1 and GCLM, and simultaneously inhibits microglial overactivation and proinflammatory cytokine secretion. By activating the Nrf2 pathway, SG16 can be used in studies on oxidative stress, ischemic stroke and acute liver injury. | |||||||||||||||||||||
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- [1]. Li S, et al. Sulfonamide-flavonoid analogue SG16 shows promise as a novel anti-inflammatory agent for ischemic stroke treatment. Bioorganic chemistry. 2026 Jun 18;180:110137. [Content Brief]
- [2]. Sang Y, et al. Fluorinated sulfonamide-flavonoid derivatives as novel Keap1-Nrf2 inhibitors: Potent induction of cytoprotective gene HO-1 in vivo. Eur J Med Chem. 2025 Jul 5;291:117650. [Content Brief]
Keywords
