3076807-15-0
Chemical Structure
WWQ-03-012
- CAS No.: 3076807-15-0
- Formula:C20H16N4O3S
- Molecular Weight:392.43
InChIKey: XCXRUESWMUGMHJ-AWEZNQCLSA-N
SMILES: O=C([C@@H]1CN(C#N)CC1)NC(S2)=NC3=C2C=CC(C4=CC(OCO5)=C5C=C4)=C3
Biological Activity: WWQ-03-012 is a selective deSUMOylating isopeptidases DESI2 inhibitor with an IC50 of 47.3 μM. WWQ-03-012 cans induce JAK2-V617F ubiquitination-proteasome degradation with no significant effect on wild-type JAK2. WWQ-03-012 can block JAK2-STAT3/5 signaling, inhibit cell proliferation and induce apoptosis. WWQ-03-012 has a synergistic effect in combination with Ruxolitinib (HY-50856), further enhancing its killing effect on JAK2 mutant cells. WWQ-03-012 can be used for the research of cancer, such as myeloproliferative neoplasms[1].
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WWQ-03-012 | 98.04% | WWQ-03-012 is a selective deSUMOylating isopeptidases DESI2 inhibitor with an IC50 of 47.3 μM. WWQ-03-012 cans induce JAK2-V617F ubiquitination-proteasome degradation with no significant effect on wild-type JAK2. WWQ-03-012 can block JAK2-STAT3/5 signaling, inhibit cell proliferation and induce apoptosis. WWQ-03-012 has a synergistic effect in combination with Ruxolitinib (HY-50856), further enhancing its killing effect on JAK2 mutant cells. WWQ-03-012 can be used for the research of cancer, such as myeloproliferative neoplasms. | ||||||||||||||||||||
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Keywords
