3080324-43-9
Chemical Structure
DRAK2-IN-2
- CAS No.: 3080324-43-9
- Formula:C22H18N4O2S
- Molecular Weight:402.47
InChIKey: IDVRLHYCFHRLTQ-UHFFFAOYSA-N
SMILES: O=C(N)C(C=C1)=CC=C1C2=CN=C(SC=C3NC(NCC4=CC=CC=C4)=O)C3=C2
Biological Activity: DRAK2-IN-2 is a selective DRAK2 inhibitor with an IC50 value of 198.5 nM. DRAK2-IN-2 inhibits DRAK2-mediated phosphorylation of ULK1 at the Ser56 site. DRAK2-IN-2 enhances insulin secretion, increases mitochondrial membrane potential, alleviates Palmitic acid (HY-N0830)-induced mitochondrial membrane potential damage and Apoptosis, and improves glucose tolerance in vivo. DRAK2-IN-2 can be used for the research of type 2 diabetes[1].
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DRAK2-IN-2 | DRAK2-IN-2 is a selective DRAK2 inhibitor with an IC50 value of 198.5 nM. DRAK2-IN-2 inhibits DRAK2-mediated phosphorylation of ULK1 at the Ser56 site. DRAK2-IN-2 enhances insulin secretion, increases mitochondrial membrane potential, alleviates Palmitic acid (HY-N0830)-induced mitochondrial membrane potential damage and Apoptosis, and improves glucose tolerance in vivo. DRAK2-IN-2 can be used for the research of type 2 diabetes. | |||||||||||||||||||||
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Keywords
