3081383-46-9
Chemical Structure
(S)-dHTC1
- CAS No.: 3081383-46-9
- Formula:C33H40N8O6S
- Molecular Weight:676.79
InChIKey: OCUSWIZQDIUKKB-XIFFEERXSA-N
SMILES: O=C(NC1CCC1)C(C=C2)=CN(C2=N3)C=C3C4=CC=CC(C(NCCN5CCC(NS(=O)(N6C[C@@]7(CC(NC7=O)=O)CC6)=O)CC5)=O)=C4
Biological Activity: (S)-dHTC1 is a stereoselective molecular glue degrader of the transcriptional coactivator ENL, binding to the ENL YEATS domain with a KD of 49 nM. After pre-forming a complex with ENL, (S)-dHTC1 cooperatively recruits CRL4CRBN through an extensive ENL-CRBN protein-protein interaction interface, promoting stereoselective ternary complex formation and inducing ENL degradation. (S)-dHTC1 can be used for research on acute myeloid leukemia (AML)[1].
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(S)-dHTC1 | (S)-dHTC1 is a stereoselective molecular glue degrader of the transcriptional coactivator ENL, binding to the ENL YEATS domain with a KD of 49 nM. After pre-forming a complex with ENL, (S)-dHTC1 cooperatively recruits CRL4CRBN through an extensive ENL-CRBN protein-protein interaction interface, promoting stereoselective ternary complex formation and inducing ENL degradation. (S)-dHTC1 can be used for research on acute myeloid leukemia (AML). | |||||||||||||||||||||
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