3081880-03-4
Chemical Structure
HDAC6-IN-53
- CAS No.: 3081880-03-4
- Formula:C26H24BrN3O4
- Molecular Weight:522.39
InChIKey: JSPWBNRQGFKZQA-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(Br)C=C1)NCCC2=CN(CC3=CC=C(C(NO)=O)C=C3)C4=CC=C(OC)C=C42
Biological Activity: HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. HDAC6-IN-53 exerts the activity of inhibiting the phenotype of idiopathic pulmonary fibrosis (IPF) by suppressing the collagen expression induced by TGF-β1, and it has demonstrated a good therapeutic effect in a mouse model of pulmonary fibrosis induced by Bleomycin (HY-17565A). HDAC6-IN-53 can be used in the research of idiopathic pulmonary fibrosis and other related pulmonary fibrosis diseases.
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HDAC6-IN-53 | HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. HDAC6-IN-53 exerts the activity of inhibiting the phenotype of idiopathic pulmonary fibrosis (IPF) by suppressing the collagen expression induced by TGF-β1, and it has demonstrated a good therapeutic effect in a mouse model of pulmonary fibrosis induced by Bleomycin (HY-17565A). HDAC6-IN-53 can be used in the research of idiopathic pulmonary fibrosis and other related pulmonary fibrosis diseases. | |||||||||||||||||||||
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Keywords
