3084696-50-1
Chemical Structure
BCL6-760
- CAS No.: 3084696-50-1
- Formula:C36H43ClN10O4
- Molecular Weight:715.24
InChIKey: UAPMBWAZZWBDFF-UHFFFAOYSA-N
SMILES: CN(C1=NC(NC2=CC=C3N(C(N(C3=C2)CCC(C)(O)C)=O)C)=C(C=N1)Cl)C4CCN(C5=CC6=C(C(C7CCC(NC7=O)=O)=NN6C)C=C5)CC4
Biological Activity: BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC50 of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317); Blue: CRBN ligand (HY-179305); Black: Linker)[1].
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BCL6-760 | BCL6-760 is an orally active BCL-6 PROTAC degrader with an EC50 of 0.8 nM. BCL6-760 only degrades BCL6 and has no effect on other CRBN substrates. BCL6-760 demonstrates significant efficacy in the orthotopic xenograft mouse model of OCI-LY-1 tumors. BCL6-760 can be used in the research of diffuse Large B-cell Lymphoma (DLBCL) (Pink: BCL-6 ligand (HY-179317); Blue: CRBN ligand (HY-179305); Black: Linker). | |||||||||||||||||||||
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Keywords
