3093409-30-1
Chemical Structure
PROTAC GSK-3β Degrader-1
- CAS No.: 3093409-30-1
- Formula:C43H42Cl2N6O9
- Molecular Weight:857.73
InChIKey: QGECSMFGVLFLIS-UHFFFAOYSA-N
SMILES: ClC1=CC(Cl)=CC=C1C(C(NC2=O)=O)=C2C3=CN(C4=CC=CC=C34)CC(NCCCOCCCCOCCCNC5=C(C6=CC=C5)C(N(C6=O)C7CCC(NC7=O)=O)=O)=O
Biological Activity: PROTAC GSK-3β Degrader-1 (compound 1) is a degrader targets GSK-3β PROTAC degrader with an IC50 value of 833 nM. PROTAC GSK-3β Degrader-1 contains SB-216763 (a GSK-3β inhibitor), a PEG linker and a CRBN (E3 ligase liand). PROTAC GSK-3β Degrader-1 reduces the neurotoxicity induced by Aβ25-35 peptide and CuSO4. PROTAC GSK-3β Degrader-1 can be used to research in Alzheimer's disease[1].
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PROTAC GSK-3β Degrader-1 | 99.05% | PROTAC GSK-3β Degrader-1 (compound 1) is a degrader targets GSK-3β PROTAC degrader with an IC50 value of 833 nM. PROTAC GSK-3β Degrader-1 contains SB-216763 (a GSK-3β inhibitor), a PEG linker and a CRBN (E3 ligase liand). PROTAC GSK-3β Degrader-1 reduces the neurotoxicity induced by Aβ25-35 peptide and CuSO4. PROTAC GSK-3β Degrader-1 can be used to research in Alzheimer's disease. | ||||||||||||||||||||
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Keywords
