3094059-45-4
3094059-45-4
Chemical Structure
UNC8900
- CAS No.: 3094059-45-4
- Formula:C75H99N17O15S
- Molecular Weight:1510.76
InChIKey: IADMWNJOSJGQFE-DAWJDFRTSA-N
SMILES: O=C(C1=CC2=C(N(C(NC(C3=CC(C)=NN3CC)=O)=N2)C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=C4C(OCCCN7CCOCC7)=CC(C(N)=O)=C6)C(OC)=C1)NCCOCCOCCOCCOCCC(N[C@H](C(C)(C)C)C(N8[C@@H](C[C@@H](O)C8)C(NCC9=CC=C(C%10=C(N=CS%10)C)C=C9)=O)=O)=O
Biological Activity: UNC8900 is a STING PROTAC degrader with a DC50 of 0.924 μM. UNC8900 binds to the Von Hippel-Lindau E3 ubiquitin ligase and recruits it to activated STING for ubiquitination and subsequent degradation. UNC8900 can be used in related research on renal cell carcinoma[1].
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UNC8900 | UNC8900 is a STING PROTAC degrader with a DC50 of 0.924 μM. UNC8900 binds to the Von Hippel-Lindau E3 ubiquitin ligase and recruits it to activated STING for ubiquitination and subsequent degradation. UNC8900 can be used in related research on renal cell carcinoma. | |||||||||||||||||||||
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