3100306-80-4
3100306-80-4
Chemical Structure
Keap1-Nrf2-IN-25
- CAS No.: 3100306-80-4
- Formula:C25H28N2O6S
- Molecular Weight:484.56
InChIKey: DAJQMPGMTNIDEM-SFHVURJKSA-N
SMILES: OC(CN(S(=O)(C1=C(C)C=C(C)C=C1C)=O)C2=CC=C(N[C@H](CC(O)=O)C)C3=CC=CC=C32)=O
Biological Activity: Keap1-Nrf2-IN-25 (Compound 19) is a potent Keap1-Nrf2 inhibitor (IC50 of 0.55 μM) with Keap1 binding affinity (Kd of 0.50 μM). Keap1-Nrf2-IN-25 activates Nrf2, reduces ROS and pro-inflammatory cytokines (IL-1β, IL-6). Keap1-Nrf2-IN-25 exerts protective effects against DSS (HY-116282)-induced colitis[1].
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Keap1-Nrf2-IN-25 | Keap1-Nrf2-IN-25 (Compound 19) is a potent Keap1-Nrf2 inhibitor (IC50 of 0.55 μM) with Keap1 binding affinity (Kd of 0.50 μM). Keap1-Nrf2-IN-25 activates Nrf2, reduces ROS and pro-inflammatory cytokines (IL-1β, IL-6). Keap1-Nrf2-IN-25 exerts protective effects against DSS (HY-116282)-induced colitis. | |||||||||||||||||||||
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References
- [1]. Zhao Z, et al. Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management. Eur J Med Chem. 2025 Feb 13;288:117384. [Content Brief]
Keywords
