3104129-77-0
Chemical Structure
PDI-IN-4
- No. CAS: 3104129-77-0
- Formula:C17H12F3NO2
- Molecular Weight:319.28
InChIKey: LJNYGIIVPODFNB-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(NC(C(C(F)(F)F)=C)=O)C=C1)C2=CC=CC=C2
Biological Activity: PDI-IN-4 is a highly selective inhibitor of human PDI (IC50=0.48 μM) with no significant cytotoxicity. PDI-IN-4 binds to PDI in a reversible manner, not only forming a covalent bond with the Cys400 residue but also engaging in hydrophobic interactions with other residues. By inhibiting the activation of GPIIb/IIIa, PDI-IN-4 effectively blocks platelet aggregation and thrombus formation. PDI-IN-4 can serve as an important tool reagent for thrombosis-related research[1].
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PDI-IN-4 | PDI-IN-4 is a highly selective inhibitor of human PDI (IC50=0.48 μM) with no significant cytotoxicity. PDI-IN-4 binds to PDI in a reversible manner, not only forming a covalent bond with the Cys400 residue but also engaging in hydrophobic interactions with other residues. By inhibiting the activation of GPIIb/IIIa, PDI-IN-4 effectively blocks platelet aggregation and thrombus formation. PDI-IN-4 can serve as an important tool reagent for thrombosis-related research. | |||||||||||||||||||||
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Keywords
