3104353-70-7
Chemical Structure
TLR7 antagonist-1
- CAS No.: 3104353-70-7
- Formula:C21H25ClF3N5O
- Molecular Weight:455.90
InChIKey: DUCNCSKRUGXAEQ-UHFFFAOYSA-N
SMILES: CC1=CN(C2=N1)C=C(C=C2OC)C3=CN=C(C(C(F)(F)F)=C3)N4CCC(C)(CC4)N.Cl
Biological Activity: TLR7 antagonist-1 (Compound 44#) is an orally active, selective TLR7 antagonist with an IC50 value of 0.3 nM against TLR7. TLR7 antagonist-1 selectively binds to TLR7, inhibits its activation, and downregulates the c-Rel signaling pathway. TLR7 antagonist-1 downregulates the mRNA levels of proinflammatory cytokines IL-1β, IL-6, and TNF-α. TLR7 antagonist-1 alleviates Imiquimod (HY-B0180)-induced psoriasis-like skin lesions. TLR7 antagonist-1 is applicable to research related to psoriasis[1].
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TLR7 antagonist-1 | TLR7 antagonist-1 (Compound 44#) is an orally active, selective TLR7 antagonist with an IC50 value of 0.3 nM against TLR7. TLR7 antagonist-1 selectively binds to TLR7, inhibits its activation, and downregulates the c-Rel signaling pathway. TLR7 antagonist-1 downregulates the mRNA levels of proinflammatory cytokines IL-1β, IL-6, and TNF-α. TLR7 antagonist-1 alleviates Imiquimod (HY-B0180)-induced psoriasis-like skin lesions. TLR7 antagonist-1 is applicable to research related to psoriasis. | |||||||||||||||||||||
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