3105103-33-8
Chemical Structure
Enpp-1-IN-27
- CAS No.: 3105103-33-8
- Formula:C13H19ClN6O3S
- Molecular Weight:374.85
InChIKey: PRBYJLIHEJSLHM-UHFFFAOYSA-N
SMILES: O=C1NC(N=CN=C2N3CCC(CNS(N)(=O)=O)(CC3)CCl)=C2C1
Biological Activity: Enpp-1-IN-27 is a selective ENPP1 inhibitor with an IC50 of 14.68 nM, exhibiting approximately 410-fold selectivity against ENPP2 and 10-fold selectivity against ENPP3. Enpp-1-IN-27 stabilizes cGAMP levels and activates the STING pathway, promoting cytokine release and enhancing innate immune responses. Enpp-1-IN-27 induces ISRE activation and amplified cGAMP-mediated immune responses and shows the desired antitumor efficacy in the 4T1 and CT26 syngeneic mouse models. Enpp-1-IN-27 can used for the studies of breast cancer and colon cancer[1].
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Enpp-1-IN-27 | Enpp-1-IN-27 is a selective ENPP1 inhibitor with an IC50 of 14.68 nM, exhibiting approximately 410-fold selectivity against ENPP2 and 10-fold selectivity against ENPP3. Enpp-1-IN-27 stabilizes cGAMP levels and activates the STING pathway, promoting cytokine release and enhancing innate immune responses. Enpp-1-IN-27 induces ISRE activation and amplified cGAMP-mediated immune responses and shows the desired antitumor efficacy in the 4T1 and CT26 syngeneic mouse models. Enpp-1-IN-27 can used for the studies of breast cancer and colon cancer. | |||||||||||||||||||||
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Keywords
