3107530-08-2
Chemical Structure
DOTA-C1-FAP-2286
- CAS No.: 3107530-08-2
- Formula:C73H109N15O26S5
- Molecular Weight:1773.06
InChIKey: QSBCTGULVNSZJA-NCAZIDMLSA-N
SMILES: OC(CN(CCN1CC(O)=O)CCN(CCN(CC1)CC(O)=O)CC(N[C@@H](CS(=O)(O)=O)C(N[C@@H](CS(=O)(O)=O)C(NCCSCC2=CC(CSC[C@H](N3)C(O)=O)=CC(CSC[C@@H](C(N4[C@](CCC4)([H])C(N5[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C3=O)CC6=CC=CC=C6)=O)CCC(N)=O)=O)[C@@H](C)O)=O)([H])CCC5)=O)=O)NC(CCCCC)=O)=C2)=O)=O)=O)=O
Biological Activity: DOTA-C1-FAP-2286 is a cysteic acid-modified fibroblast activation protein (FAP)-targeting radioligand. DOTA-C1-FAP-2286 binds competitively to FAP with an IC50 of 127.64 nM. DOTA-C1-FAP-2286 is targeted accumulation in FAP-expressing cells and exhibits accelerated renal clearance. DOTA-C1-FAP-2286 can be used as a PET/CT tracer in cancer[1].
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DOTA-C1-FAP-2286 | DOTA-C1-FAP-2286 is a cysteic acid-modified fibroblast activation protein (FAP)-targeting radioligand. DOTA-C1-FAP-2286 binds competitively to FAP with an IC50 of 127.64 nM. DOTA-C1-FAP-2286 is targeted accumulation in FAP-expressing cells and exhibits accelerated renal clearance. DOTA-C1-FAP-2286 can be used as a PET/CT tracer in cancer. | |||||||||||||||||||||
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Keywords
