31078-12-3
Chemical Structure
Alytesin
- CAS No.: 31078-12-3
- Formula:C68H106N22O17S
- Molecular Weight:1535.77
IUPAC Name: (S)-N1-((5S,8S,11S,17S,20S,23S)-11-((1H-imidazol-4-yl)methyl)-5-carbamoyl-24-(1H-indol-3-yl)-8-isobutyl-17-isopropyl-20-methyl-7,10,13,16,19,22-hexaoxo-2-thia-6,9,12,15,18,21-hexaazatetracosan-23-yl)-2-((6S,9S,15S)-6-(3-guanidinopropyl)-15-((R)-1-hydroxyethyl)-9-isobutyl-1,4,7,10,13-pentaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14-pentaazahexadecan-16-amido)pentanediamide
InChIKey: ISGGITPLKHZHOL-TXYKKBLVSA-N
SMILES: O=C([C@@H](N1)CCC1=O)NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(NCC(N[C@]([C@H](O)C)([H])C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C(C)C)C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CCSC)=O)=O)CC2=CNC=N2)=O)=O)=O)=O)CC3=CNC4=C3C=CC=C4)=O)=O)=O)=O)=O)=O
Biological Activity: Alytesin, a bombesin-like peptide, is found in extracts of the skin of Alytes obstetricans. Alytesin reduces gastric acid secretion and induces hypertension. Alytesin also induces short-term anorexigenic effects in neonatal chicks[1][2][3]
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Alytesin | Alytesin, a bombesin-like peptide, is found in extracts of the skin of Alytes obstetricans. Alytesin reduces gastric acid secretion and induces hypertension. Alytesin also induces short-term anorexigenic effects in neonatal chicks | |||||||||||||||||||||
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References
- [1]. Guglietta A, et al. Central neuromodulation of gastric acid secretion by bombesin-like peptides. Peptides. 1985;6 Suppl 3:75-81. [Content Brief]
- [2]. Erspamer V, et al. Some pharmacological actions of alytesin and bombesin. J Pharm Pharmacol. 1970 Nov;22(11):875-6. [Content Brief]
- [3]. Cline MA, et al. Central and peripheral alytesin cause short-term anorexigenic effects in neonatal chicks. Neuropeptides. 2008 Jun;42(3):283-91. [Content Brief]
