3112948-91-8
3112948-91-8
Chemical Structure
Ac-Lys(CoA)-NH2 TFA
Synonym(s): Ac-Lys(coenzyme A)-NH2 TFA
- CAS No.: 3112948-91-8
- Formula:C33H54F3N10O21P3S
- Molecular Weight:1108.82
InChIKey: SGCAYGMHHNOYEY-JPBLFTSTSA-N
SMILES: O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(NCCCC[C@@H](C(N)=O)NC(C)=O)=O)=O)=O)(O)=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C32.O=C(O)C(F)(F)F
Biological Activity: Ac-Lys(CoA)-NH2 TFA (Ac-Lys(coenzyme A)-NH2 TFA) is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of approximately 50 nM or 500 nM[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ac-Lys(CoA)-NH2 TFA | 98.52% | Ac-Lys(CoA)-NH2 TFA (Ac-Lys(coenzyme A)-NH2 TFA) is a selective p300 histone acetyltransferase (HAT) inhibitor with an IC50 of approximately 50 nM or 500 nM. | ||||||||||||||||||||
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References
- [1]. Cebrat M, et al. Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorganic & medicinal chemistry. 2003 Jul 31;11(15):3307-13. [Content Brief]
- [2]. Lau OD, et al. HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Molecular cell. 2000 Mar;5(3):589-95. [Content Brief]
- [3]. Cole PA, et al. Chemical probes for histone-modifying enzymes. Nature chemical biology. 2008 Oct;4(10):590-7. [Content Brief]
