3117527-91-7
Chemical Structure
IKKβ-IN-6
- CAS No.: 3117527-91-7
- Formula:C43H38N2O11
- Molecular Weight:758.77
InChIKey: NHCOEPWPNSPBHV-QMDZDMHNSA-N
SMILES: O=C(C([C@@H]1CC/C(COC(C2=CC=CC=C2C(OC3=CC4=CC5=C(N=C4C=C3)C6=CC7=C(C(N6C5)=O)COC([C@]7(O)CC)=O)=O)=O)=C\CC8)=C)O[C@@H]1[C@H]9O[C@@]98C
Biological Activity: IKKβ-IN-6 is an antitumor agent. IKKβ-IN-6 inhibits IKKβ (IC50: 18.24 μM), thereby suppressing the phosphorylation of p65 and IκBα, blocking the nuclear translocation of p65, and subsequently regulating genes controlled by NF-κB. IKKβ-IN-6 also targets topoisomerase I (Topo I), induces DNA damage, ROS accumulation, loss of mitochondrial membrane potential, and S-phase arrest. IKKβ-IN-6 is applicable to related research on colorectal cancer[1].
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IKKβ-IN-6 | IKKβ-IN-6 is an antitumor agent. IKKβ-IN-6 inhibits IKKβ (IC50: 18.24 μM), thereby suppressing the phosphorylation of p65 and IκBα, blocking the nuclear translocation of p65, and subsequently regulating genes controlled by NF-κB. IKKβ-IN-6 also targets topoisomerase I (Topo I), induces DNA damage, ROS accumulation, loss of mitochondrial membrane potential, and S-phase arrest. IKKβ-IN-6 is applicable to related research on colorectal cancer. | |||||||||||||||||||||
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